Does size matter? In search of a physiological definition of myocardial atrophy.

while platelet aggregation returned to baseline after 7 to 8 weeks (5). We also demonstrated a progressive reduction in platelet sensitivity to aspirin in longterm aspirin-treated patients. The genomic response to a pharmacological “challenge” with aspirin has also been demonstrated. After aspirin administration, a set of platelet-enriched genes and proteins associated with platelet function and cardiovascular complications have been identified. Moreover, increased platelet expression of glycoprotein IIIa with aspirin treatment has been demonstrated. In conclusion, we suggest a better definition of the impact of prior aspirin use, because the capability of aspirin in changing protein platelet expression may be useful to better understand high on-aspirin treatment platelet reactivity.